ADRA2B Antibodies

AND ADRA2B ELISA kits, ADRA2B Proteins

Many biological assays use antibodies to detect ADRA2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADRA2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADRA2B antibodies...

We validate the specificity of these antibodies to ADRA2B by testing them on tissues known to express ADRA2B positively and negatively. Browse below to find the ADRA2B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADRA2B Infographic by Boster Bio

All ADRA2B Products

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Anti-Adrenergic Receptor alpha-2B ADRA2B Antibody

4 Q&As

Human

$360
Cat # A03622
100 µl

Anti-Alpha-2B adrenergic receptor ADRA2B Antibody

Human, Mouse, Rat

$405
Cat # A03622-1
100ul

ADRA2B Overview

Facts about Alpha-2B adrenergic receptor.

ADRA2B 3D structure. Source: alphafold

Alpha-2B adrenergic receptor (ADRA2B)

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.

For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. .

Gene Information

Human
Gene Name:	ADRA2B
Uniprot:	P18089
Entrez:	151

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

a-2B AdrenergicR; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2B; ADRA2L1; ADRA2L1adrenergic receptor alpha 2B; ADRA2RL1; ADRARL1; adrenergic, alpha-2B-, receptor; Alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha-2B Adrenergic R; alpha-2B adrenergic receptor; alpha2B AdrenergicR; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; ALPHA2BAR; alpha-2BAR; G-protein coupled receptor

Molecular Weight

Mass (kDA):
49.954 kDA

Genomic Context


Human

Location:	2q11.2
Sequence:	2; NC_000002.12 (96112876..96116571, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane.

Diseases

Hypertensive Disease
Nervousness
Pathologic Vasoconstriction
Diabetes Mellitus
Obesity
Pertussis
Diabetes Mellitus, Non-insulin-dependent
Essential Hypertension
Cardiovascular Diseases
Coronary Heart Disease
Sudden Cardiac Death
Cardiac Death
Disease Of Adrenal Medulla

Tumor Angiogenesis
Malignant Neoplasms
Mental Disorders
Hypertrophy
Von Willebrand Disease
Myocardial Ischemia
Stenosis

Interacting Proteins

ACKR3
RAB26

Pathways

Vasoconstriction
Transport
Localization
Secretion
Insulin Secretion
Protein Transport
Angiogenesis
Cell Proliferation
Aging
Brain Development
Fibroblast Proliferation
Endothelial Cell Proliferation
Reflex

Reverse Transcription
Cell Cycle
Cognition
Receptor Transactivation
Regulation Of Blood Pressure
Righting Reflex
Secretory Pathway

PTMs

Phosphorylation

Glycosylation

Biotinylation

Research Areas

Adaptive Immunity
Immunology
Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADRA2B

References

PMID: 2164221 by Lomasney J.W., et al. Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

PMID: 2172775 by Weinshank R.L., et al. Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.