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Product Info Summary
| SKU: | A10066 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-ZIP12 SLC39A12 Antibody
SKU/Catalog Number
A10066
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ZIP12 SLC39A12 Antibody (Catalog # A10066). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
ZIP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ZIP12 SLC39A12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10066)
Host
Rabbit
Contents
ZIP12 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ZIP12 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZIP12. The immunogen is located within the first 50 amino acids of ZIP12.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of ZIP12 are known to exist. ZIP12 antibody is predicted to not cross-react with other ZIP family members.
Reactive Species
A10066 is reactive to SLC39A12 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
76666 MW
Background of SLC39A12
The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10066 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZIP12 antibody can be used for detection of ZIP12 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZIP12 in HepG2 cell lysate with ZIP12 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of ZIP12 in mouse liver tissue with ZIP12 antibody at 2.5 μg/mL.
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Immunofluorescence of ZIP12 in mouse liver tissue with ZIP12 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SLC39A12 (Source: Uniprot.org, NCBI)
Gene Name
SLC39A12
Full Name
Zinc transporter ZIP12
Weight
76666 MW
Superfamily
ZIP transporter (TC 2.A.5) family
Alternative Names
ZIP-12, LZT-Hs8, bA570F3.1, ZIP12, Zinc transporter ZIP12, LIV-1 subfamily of ZIP zinc transporter 8 SLC39A12 LZT-Hs8, ZIP-12, bA570F3.1 solute carrier family 39 member 12 zinc transporter ZIP12|LIV-1 subfamily of ZIP zinc transporter 8|solute carrier family 39 (metal ion transporter), member 12|solute carrier family 39 (zinc transporter), member 12|zrt- and Irt-like protein 12
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SLC39A12, check out the SLC39A12 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SLC39A12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ZIP12 SLC39A12 Antibody (A10066)
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