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Product Info Summary
| SKU: | A01310 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Zinc transporter 8 SLC30A8 Antibody
View all ZnT-8/SLC30A8 Antibodies
SKU/Catalog Number
A01310
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Zinc transporter 8 SLC30A8 Antibody (Catalog # A01310). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
SLC30A8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Zinc transporter 8 SLC30A8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01310)
Host
Rabbit
Contents
SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two isoforms of SLC30A8 are known to exist; this antibody will detect both isoforms. This SLC30A8 antibody is predicted to not cross-react with other members of the SLC30 protein family.
Reactive Species
A01310 is reactive to SLC30A8 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
40755 MW
Background of ZnT-8/SLC30A8
SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in -cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01310 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SLC30A8 antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SLC30A8 in human pancreas tissue lysate with SLC30A8 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide
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Immunohistochemistry of SLC30A8 in human pancreas tissue with SLC30A8 Antibody at 5 μg/mL.
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Immunofluorescence of SLC30A8 in human pancreas tissue with SLC30A8 Antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SLC30A8 (Source: Uniprot.org, NCBI)
Gene Name
SLC30A8
Full Name
Zinc transporter 8
Weight
40755 MW
Superfamily
cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Alternative Names
Solute carrier family 30 member 8, zinc transporter 8, ZNT8, Zn-T8 SLC30A8 ZNT8, ZnT-8 solute carrier family 30 member 8 zinc transporter 8|solute carrier family 30 (zinc transporter), member 8|zinc transporter ZnT-8
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SLC30A8, check out the SLC30A8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SLC30A8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Zinc transporter 8 SLC30A8 Antibody (A01310)
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