Anti-UBR1 Antibody

Product Name

Anti-UBR1 Antibody

View all Ubr1 Antibodies

SKU/Catalog Number

A03250

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-UBR1 Antibody (Catalog # A03250). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-UBR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03250)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human UBR1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03250 is reactive to UBR1 in Human, Mouse

Reconstitution

Calculated molecular weight

200211 MW

Background of Ubr1

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Kwak K.S., Cancer Res. 64:8193-8198(2004).
Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03250 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For UBR1 (Source: Uniprot.org, NCBI)

Alternative Names

E3 ubiquitin-protein ligase UBR1;6.3.2.-;N-recognin-1;Ubiquitin-protein ligase E3-alpha-1;Ubiquitin-protein ligase E3-alpha-I;UBR1; Ubr1|AI504731|ubiquitin protein ligase E3 component n-recognin 1|E3 ubiquitin-protein ligase UBR1|E3 alpha|N-recognin-1|RING-type E3 ubiquitin transferase UBR1|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I|ubiquitin-protein ligase e3 componen n-recognin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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