Ubr1 Antibodies

AND Ubr1 ELISA kits, Ubr1 Proteins

Many biological assays use antibodies to detect Ubr1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ubr1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ubr1 antibodies...

We validate the specificity of these antibodies to Ubr1 by testing them on tissues known to express Ubr1 positively and negatively. Browse below to find the Ubr1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Ubr1 Infographic by Boster Bio

All Ubr1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-UBR1 Antibody

3 Q&As

Human, Mouse

$360
Cat # A03250
100 µl

Anti-Ubr1 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A03250-1
100ul

UBR1 (NM_174916) Human Over-expression Lysate

Human

$960
Cat # LS197131
100 µg

Ubr1 Overview

Facts about E3 ubiquitin-protein ligase UBR1.

E3 ubiquitin-protein ligase UBR1 (Ubr1)

E3 ubiquitin-protein ligase that is a part of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing in line with the N-end rule, resulting in their ubiquitination and subsequent degradation.

May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).

Gene Information

Mouse
Gene Name:	Ubr1
Uniprot:	O70481
Entrez:	22222

Family

Belongs to:

UBR1 family

Alternative Names

E3 ubiquitin-protein ligase UBR1; E3a ligase; EC 6.3.2.-; JBS; MGC142065; MGC142067; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin protein ligase E3 component n-recognin 1; ubiquitin-protein ligase E3-alpha; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I

Molecular Weight

Mass (kDA):
200.24 kDA

Genomic Context


Mouse

Location:	2 E5\|2 60.37 cM
Sequence:	2;

Tissue Specificity

Present in skeletal muscle and liver (at protein level). Broadly expressed, with highest levels in skeletal muscle and heart. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatogonia.

Diseases

Johanson-blizzard Syndrome
Exocrine Pancreatic Insufficiency
Pancreatic Insufficiency
Hypothyroidism
Pancreatic Diseases
Sensorineural Hearing Loss (disorder)
Anus, Imperforate
Ectodermal Dysplasia
Growth Disorders
Complete Hearing Loss
Malignant Neoplasms
Aplasia, Nos

Neoplasms
Dwarfism
Pancreatitis
Diabetes Mellitus
Hypoplasia
Inflammation
Developmental Delay (disorder)

Pathways

Proteolysis
Conjugation
Dna Repair
Sporulation
Meiosis
Dna Replication
Transport
Peptide Transport
Cell Cycle
Localization
Cell Growth
Nuclear Export
Dna Damage Checkpoint

Mating
Muscle Atrophy
Pachytene
Hypersensitivity
Anaphase
Prophase
Male Meiosis

PTMs

Ubiquitination
Phosphorylation
Cleavage
Demethylation

Reduction
Oxidation
Methylation
Deamidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ubr1

References

PMID: 9653112 by Kwon Y.T., et al. The mouse and human genes encoding the recognition component of the N-end rule pathway.

PMID: 11689692 by Kwon Y.T., et al. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.