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Product Info Summary
| SKU: | A00940 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TREX1 Antibody
SKU/Catalog Number
A00940
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TREX1 Antibody (Catalog # A00940). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TREX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TREX1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00940)
Host
Rabbit
Contents
TREX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TREX1 antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1. The immunogen is located within amino acids 220 - 270 of TREX1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TREX1 antibody will not cross-react with the related protein TREX2. At least three isoforms of TREX1 are known to exist; this antibody will recognize all three isoforms.
Reactive Species
A00940 is reactive to TREX1 in Human, Mouse, Rat
Applications
A00940 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
33212 MW
Background of TREX1
Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TREX1 antibody can be used for detection of TREX1 by Western blot at 0.5 and 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of TREX1 in human spleen tissue with TREX1 antibody at 2.5 μg/mL.
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Immunofluorescence of TREX1 in Human Spleen tissue with TREX1 antibody at 20 μgg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TREX1 (Source: Uniprot.org, NCBI)
Gene Name
TREX1
Full Name
Three-prime repair exonuclease 1
Weight
33212 MW
Superfamily
exonuclease superfamily
Alternative Names
3'-5' exonuclease TREX1; AGS1; Aicardi-Goutieres syndrome 1; CRV; DKFZp434J0310; DNase III; DRN3; EC 3.1.11.2; HERNS; three prime repair exonuclease 1,3' repair exonuclease 1 TREX1 AGS1, CRV, DRN3, HERNS, RVCLS three prime repair exonuclease 1 three-prime repair exonuclease 1|3 repair exonuclease 1|3-5 exonuclease TREX1|DNase III|deoxyribonuclease III
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TREX1, check out the TREX1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TREX1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TREX1 Antibody (A00940)
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