TREX1 Antibodies

AND TREX1 ELISA kits, TREX1 Proteins

Many biological assays use antibodies to detect TREX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TREX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TREX1 antibodies...

We validate the specificity of these antibodies to TREX1 by testing them on tissues known to express TREX1 positively and negatively. Browse below to find the TREX1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TREX1 Infographic by Boster Bio

All TREX1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TREX1 Antibody Picoband®

1 Q&As

Human

$370
Cat # PB9748
100 μg/vial

Anti-TREX1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A00940
0.1 mg

Anti-TREX1 Antibody

Human

IF, IHC, ICC, WB

$405
Cat # A00940-1
100ul

Anti-TREX1 Rabbit Monoclonal Antibody

Human

IF, IHC, ICC, WB

$370
Cat # M00940-1
100 μl/vial

TREX1 (NM_016381) Human Over-expression Lysate

Human

$628
Cat # LS011277
100 µg

TREX1 Overview

Facts about Three-prime repair exonuclease 1.

TREX1 3D structure. Source: alphafold

Three-prime repair exonuclease 1 (TREX1)

Major mobile 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Acts by metabolizing DNA fragments from endogenous retroelements, such as L1, LTR and SINE elements.

Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) reaction and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates.

Gene Information

Human
Gene Name:	TREX1
Uniprot:	Q9NSU2
Entrez:	11277

Family

Belongs to:

exonuclease superfamily

Alternative Names

3'-5' exonuclease TREX1; AGS1; Aicardi-Goutieres syndrome 1; CRV; DKFZp434J0310; DNase III; DRN3; EC 3.1.11.2; HERNS; three prime repair exonuclease 1,3' repair exonuclease 1

Molecular Weight

Mass (kDA):
33.212 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (48465830..48467645)

Tissue Specificity

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

Subcellular Localizations

Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death.