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Product Info Summary
| SKU: | A09364 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Transmembrane protein 59 TMEM59 Antibody
SKU/Catalog Number
A09364
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transmembrane protein 59 TMEM59 Antibody (Catalog # A09364). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
TMEM59 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transmembrane protein 59 TMEM59 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09364)
Host
Rabbit
Contents
TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59. The immunogen is located within amino acids 80 - 130 of TMEM59.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Although antibody should react with both isoforms, only the Bcl-GS protein has been observed
Reactive Species
A09364 is reactive to TMEM59 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
36223 MW
Background of TMEM59
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09364 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM59 antibody can be used for detection of TMEM59 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 μg/mL.
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Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMEM59 (Source: Uniprot.org, NCBI)
Gene Name
TMEM59
Full Name
Transmembrane protein 59
Weight
36223 MW
Superfamily
TMEM59 family
Alternative Names
C1orf8, HSPC001, C1orf8, UNQ169/PRO195, Transmembrane protein 59, Liver membrane-bound protein TMEM59 C1orf8, DCF1, HSPC001, PRO195, UNQ169 transmembrane protein 59 transmembrane protein 59|dendritic cell factor 1|liver membrane-bound protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMEM59, check out the TMEM59 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMEM59: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transmembrane protein 59 TMEM59 Antibody (A09364)
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