Transmembrane protein 59 Antibodies

AND TMEM59 ELISA kits, Transmembrane protein 59 Proteins

Many biological assays use antibodies to detect Transmembrane protein 59, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 59 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 59 antibodies...

We validate the specificity of these antibodies to Transmembrane protein 59 by testing them on tissues known to express TMEM59 positively and negatively. Browse below to find the TMEM59 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMEM59 Infographic by Boster Bio

All TMEM59 Products

Product

Figures

Specificity

Applications

Price

Anti-Transmembrane protein 59 TMEM59 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A09364
0.1 mg

TMEM59 (NM_004872) Human Recombinant Protein

$1249
Cat # PROTQ9BXS4
20 µg

TMEM59 (NM_004872) Human Over-expression Lysate

Human

$628
Cat # LS009528
100 µg

Anti-TMEM59 Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A09364-1
100 µg/vial

TMEM59 Overview

Facts about Transmembrane protein 59.

TMEM59 3D structure. Source: alphafold

Transmembrane protein 59 (TMEM59)

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C).

Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and boosting LC3 lipidation and following activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring throughout the Golgi maturation of several proteins like APP, BACE1, SEAP or PRNP (PubMed:20427278).

Gene Information

Human
Gene Name:	TMEM59
Uniprot:	Q9BXS4
Entrez:	9528

Family

Belongs to:

TMEM59 family

Alternative Names

C1orf8; chromosome 1 open reading frame 8; DCF1; FLJ42977; HSPC001; Liver membrane-bound protein; PRO195; TMEM59; transmembrane protein 59; UNQ169

Molecular Weight

Mass (kDA):
36.223 kDA

Genomic Context


Human

Location:	1p32.3
Sequence:	1; NC_000001.11 (54026681..54053573, complement)

Subcellular Localizations

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.

Diseases

Alzheimer's Disease
Nervousness
Neurodegenerative Disorders
Senile Plaques
Neurofibrillary Tangles

Interacting Proteins

ATG16L1

Pathways

Glycosylation
Localization
Methylation
System Development
Cell Development
Nervous System Development
Dna Methylation
Cell Morphogenesis

Pathogenesis
Secretion

PTMs

Glycosylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM59

References

PMID: 20427278 by Ullrich S., et al. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.

PMID: 23376921 by Boada-Romero E., et al. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.