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Product Info Summary
| SKU: | A09944 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TMEM38B Antibody
SKU/Catalog Number
A09944
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TMEM38B Antibody (Catalog # A09944). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM38B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TMEM38B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09944)
Host
Rabbit
Contents
TMEM38B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMEM38B antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B. The immunogen is located within the last 50 amino acids of TMEM38B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
Reactive Species
A09944 is reactive to TMEM38B in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
32510 MW
Background of Tmem38b
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09944 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of TMEM38B in mouse thymus tissue with TMEM38B antibody at 5 μg/mL.
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Immunofluorescence of TMEM38B in mouse thymus tissue with TMEM38B antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMEM38B (Source: Uniprot.org, NCBI)
Gene Name
TMEM38B
Full Name
Trimeric intracellular cation channel type B
Weight
32510 MW
Superfamily
TMEM38 family
Alternative Names
OI14, TRICB, TRIC-B, C9orf87, D4Ertd89e, bA219P18.1, Trimeric intracellular cation channel type B, Transmembrane protein 38B Tmem38b|1600017F22Rik, AA437809, AV051057, D4Ertd89, D4Ertd89e, TRIC, TRIC-B, mg33b|transmembrane protein 38B|trimeric intracellular cation channel type B|Mitsugumin33B|TRICB|mitsugumin-33B
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMEM38B, check out the TMEM38B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMEM38B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TMEM38B Antibody (A09944)
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