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- Table of Contents
9 Citations 17 Q&As
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Facts about Microtubule-associated protein tau.
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Human | |
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Gene Name: | MAPT |
Uniprot: | P10636 |
Entrez: | 4137 |
Belongs to: |
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No superfamily |
DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MGC138549; microtubule-associated protein tau; MSTD; MSTDMAPTL; MTBT1; MTBT1Neurofibrillary tangle protein; MTBT2; Neurofibrillary tangle protein; PHF-tau; PPND; Tau; TAUPaired helical filament-tau
Mass (kDA):
78.928 kDA
Human | |
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Location: | 17q21.31 |
Sequence: | 17; NC_000017.11 (45894382..46028334) |
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
PMID: 3131773 by Goedert M., et al. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
PMID: 2498079 by Goedert M., et al. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
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