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Product Info Summary
| SKU: | A02516-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Stk39 Antibody
SKU/Catalog Number
A02516-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Stk39 Antibody (Catalog # A02516-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Stk39 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Stk39 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02516-1)
Host
Rabbit
Contents
Stk39 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Stk39 antibody was raised against a 18 amino acid synthetic peptide from near the center of human Stk39. The immunogen is located within amino acids 360 - 410 of Stk39.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
Reactive Species
A02516-1 is reactive to STK39 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
59474 MW
Background of STK39
The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02516-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Stk39 antibody can be used for detection of Stk39 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Stk39 in rat brain tissue lysate with Stk39 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of Stk39 in human brain tissue with Stk39 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For STK39 (Source: Uniprot.org, NCBI)
Gene Name
STK39
Full Name
STE20/SPS1-related proline-alanine-rich protein kinase
Weight
59474 MW
Superfamily
protein kinase superfamily
Alternative Names
DCHT, PASK, SPAK, DCHT, Ste-20-related kinase STK39 DCHT, PASK, SPAK serine/threonine kinase 39 STE20/SPS1-related proline-alanine-rich protein kinase|STE20/SPS1 homolog|Ste20-like protein kinase|proline-alanine-rich STE20-related kinase|serine threonine kinase 39 (STE20/SPS1 homolog, yeast)|serine/threonine-protein kinase 39|small intestine SPAK-like kinase|ste-20-related kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on STK39, check out the STK39 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for STK39: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Stk39 Antibody (A02516-1)
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