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Product Info Summary
| SKU: | A10403 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-SIPA1L3 Antibody
SKU/Catalog Number
A10403
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SIPA1L3 Antibody (Catalog # A10403). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SIPA1L3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SIPA1L3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10403)
Host
Rabbit
Contents
SIPA1L3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SIPA1L3 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SIPA1L3. The immunogen is located within amino acids 80 - 130 of SIPA1L3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Reactive Species
A10403 is reactive to SIPA1L3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
194610 MW
Background of SIPA1L3
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10403 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SIPA1L3 antibody can be used for detection of SIPA1L3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SIPA1L3 in SK-N-SH lysate with SIPA1L3 antibody at 1 μg/mL.
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Immunohistochemistry of SIPA1L3 in human brain tissue with SIPA1L3 antibody at 5 μg/mL.
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Immunofluorescence of SIPA1L3 in Human Brain cells with SIPA1L3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SIPA1L3 (Source: Uniprot.org, NCBI)
Gene Name
SIPA1L3
Full Name
Signal-induced proliferation-associated 1-like protein 3
Weight
194610 MW
Alternative Names
SPAL3, KIAA0545, SPAL3, Signal-induced proliferation-associated 1-like protein 3, SPA-1-like protein 3, SIPA1-like protein 3 SIPA1L3 CTRCT45, SPAL3, SPAR3 signal induced proliferation associated 1 like 3 signal-induced proliferation-associated 1-like protein 3|SIPA1-like protein 3|SPA-1-like protein 3|spine-associated RapGAP 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SIPA1L3, check out the SIPA1L3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SIPA1L3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SIPA1L3 Antibody (A10403)
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