Anti-Sepiapterin reductase SPR Antibody

Product Name

Anti-Sepiapterin reductase SPR Antibody

View all SPR Antibodies

SKU/Catalog Number

A00416

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Sepiapterin reductase SPR Antibody catalog # A00416. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Sepiapterin reductase SPR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00416)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

A synthetic peptide of human SPR.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with eNOS or nNOS.

Reactive Species

A00416 is reactive to SPR in Human, Mouse, Rat

Applications

A00416 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

28048 MW

Background of SPR

Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Kan-Tai Hsia, Development, Jan 2003; 130: 369.
Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.
Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.
Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

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Western blot analysis of extracts of various cells, using SPR antibody.

Gene/Protein Information For SPR (Source: Uniprot.org, NCBI)

Alternative Names

EC 1.1.1.153; Gm10328; SDR38C1; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); sepiapterin reductase; short chain dehydrogenase/reductase family 38C, member 1; SPR SPR SDR38C1 sepiapterin reductase sepiapterin reductase|Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)|sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)|short chain dehydrogenase/reductase family 38C, member 1

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