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Product Info Summary
| SKU: | A04186-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-ROS1 Antibody (C-term)
SKU/Catalog Number
A04186-1
Size
80 µl
Description
Boster Bio Anti-ROS1 Antibody (C-term) (Catalog # A04186-1). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-ROS1 Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04186-1)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This ROS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04186-1 is reactive to ROS1 in Human
Applications
A04186-1 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
263915 Da
Background of ROS
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
Validation Images & Assay Conditions
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Western blot analysis of lysate from U-87 MG cell line, using ROS1 Antibody (C-term). A04186-1 was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Protein Target Info & Infographic
Gene/Protein Information For ROS1 (Source: Uniprot.org, NCBI)
Gene Name
ROS1
Full Name
Proto-oncogene tyrosine-protein kinase ROS
Weight
263915 Da
Superfamily
protein kinase superfamily
Alternative Names
proto-oncogene tyrosine-protein kinase ROS; c-ros oncogene 1, receptor tyrosine kinase; c-ros-1; MCF3; ROS ROS1 MCF3, ROS, c-ros-1 ROS proto-oncogene 1, receptor tyrosine kinase proto-oncogene tyrosine-protein kinase ROS|ROS proto-oncogene 1 , receptor tyrosine kinase|c-ros oncogene 1 , receptor tyrosine kinase|proto-oncogene c-Ros-1|transmembrane tyrosine-specific protein kinase|v-ros avian UR2 sarcoma virus oncogene homolog 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ROS1, check out the ROS1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ROS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ROS1 Antibody (C-term) (A04186-1)
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No publications found for A04186-1
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