ROS1 Antibodies

AND ROS1 ELISA kits, ROS1 Proteins

Many biological assays use antibodies to detect ROS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ROS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ROS1 antibodies...

We validate the specificity of these antibodies to ROS1 by testing them on tissues known to express ROS1 positively and negatively. Browse below to find the ROS1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ROS1 Infographic by Boster Bio

All ROS1 Products

Product

Figures

Specificity

Applications

Price

Anti-ROS (phospho-Y2114) ROS1 Antibody

Human, Mouse, Rat

$482
Cat # A04186Y2114
100ul

Anti-ROS1 Antibody

Human, Mouse, Rat

IHC

$380
Cat # A04186
100ul

Anti-ROS1 Antibody (C-term)

Human

$298
Cat # A04186-1
80 µl

Anti-ROS1 Mouse Monoclonal Antibody [Clone ID: OTI1F3]

Human

IF, IHC, WB

$523
Cat # M04186
100 µl

ROS1 Overview

Facts about Proto-oncogene tyrosine-protein kinase ROS.

ROS1 3D structure. Source: alphafold

Proto-oncogene tyrosine-protein kinase ROS (ROS1)

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway.

Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to restrain anchorage-independent cell growth.

Gene Information

Human
Gene Name:	ROS1
Uniprot:	P08922
Entrez:	6098

Family

Belongs to:

protein kinase superfamily

Alternative Names

proto-oncogene tyrosine-protein kinase ROS; c-ros oncogene 1, receptor tyrosine kinase; c-ros-1; MCF3; ROS

Molecular Weight

Mass (kDA):
263.915 kDA

Genomic Context


Human

Location:	6q22.1
Sequence:	6; NC_000006.12 (117287918..117426065, complement)

Tissue Specificity

Expressed in brain. Expression is increased in primary gliomas.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Lung
Non-small Cell Lung Carcinoma
Glioblastoma
Infertility
Lung Neoplasms
Adenocarcinoma
Malignant Paraganglionic Neoplasm
Glioma
Cell Transformation, Neoplastic
Infarction
Male Infertility

Lymphoma
Myocardial Infarction
Anaplastic Lymphoma
Carcinoma
Astrocytoma
Brain Neoplasms
Cholangiocarcinoma

Interacting Proteins

PTPN1
PTPN6

Pathways

Methylation
Dna Methylation
Gene Silencing
Demethylation
Dna Demethylation
Rna-directed Dna Methylation
Dna Hypermethylation
Localization
Dna Repair
Cell Death
Mating
Pathogenesis
Transport

Secretion
Cell Division
Chromatin Modification
Chromatin Remodeling
Glycosylation
Dna Replication
Fertilization

PTMs

Methylation
Demethylation
Phosphorylation

Cleavage
Dephosphorylation
Glycosylation

Acetylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROS1

References

PMID: 2352949 by Birchmeier C., et al. Characterization of ROS1 cDNA from a human glioblastoma cell line.

PMID: 3023956 by Matsushime H., et al. Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.