Anti-PTH-rP PTHLH Antibody

Product Name

Anti-PTH-rP PTHLH Antibody

View all PTHLH/PTHrP Antibodies

SKU/Catalog Number

A01321

Size

100μl

Form

Liquid

Description

Boster Bio Anti-PTH-rP PTHLH Antibody catalog # A01321. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PTH-rP PTHLH Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01321)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from PTH-rP at AA range: 101-150.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01321 is reactive to PTHLH in Human

Applications

A01321 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

20194 MW

Background of PTHLH/PTHrP

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019.
McKinsey TA, et al. (2000) Nature. 408(6808): 106-111.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of HeLa cells using PTH-rP Polyclonal antibody diluted at 1:800.

Gene/Protein Information For PTHLH (Source: Uniprot.org, NCBI)

Alternative Names

BDE2; HHM; MGC14611; Osteostatin; parathyroid hormone-like hormone; Parathyroid hormone-like protein; parathyroid hormone-related protein; PLPosteostatin; PTHLH; PTHR; PTH-related protein; PTHRP; PTH-rP; PTHRPparathyroid hormone-like related protein PTHLH BDE2, HHM, PLP, PTHR, PTHRP parathyroid hormone like hormone parathyroid hormone-related protein|PTH-rP|PTH-related protein|osteostatin|parathyroid hormone-like hormone preproprotein|parathyroid hormone-like related protein

For more info on PTHLH, check out the PTHLH Infographic

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In this infographic, you will see the following information for PTHLH: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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