PTHLH Antibodies

AND PTHLH ELISA kits, PTHLH Proteins

Many biological assays use antibodies to detect PTHLH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTHLH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTHLH antibodies...

We validate the specificity of these antibodies to PTHLH by testing them on tissues known to express PTHLH positively and negatively. Browse below to find the PTHLH antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTHLH Infographic by Boster Bio

All PTHLH Products

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Specificity

Applications

Price

Anti-PTH-rP PTHLH Antibody

3 Q&As

Human

$399
Cat # A01321
100μl

Parathyroid hormone related protein (PTHLH) (NM_198965) Human Over-expression Lysate

Human

$628
Cat # LS005744
100 µg

PTHLH Overview

Facts about Parathyroid hormone-related protein.

PTHLH 3D structure. Source: alphafold

Parathyroid hormone-related protein (PTHLH)

Neuroendocrine peptide that's a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth.

Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs.

Gene Information

Human
Gene Name:	PTHLH
Uniprot:	P12272
Entrez:	5744

Family

Belongs to:

parathyroid hormone family

Alternative Names

BDE2; HHM; MGC14611; Osteostatin; parathyroid hormone-like hormone; Parathyroid hormone-like protein; parathyroid hormone-related protein; PLPosteostatin; PTHLH; PTHR; PTH-related protein; PTHRP; PTH-rP; PTHRPparathyroid hormone-like related protein

Molecular Weight

Mass (kDA):
20.194 kDA

Genomic Context


Human

Location:	12p11.22
Sequence:	12; NC_000012.12 (27958084..27972864, complement)

Tissue Specificity

Ubiquitous. Also expressed in the mammary gland.

Subcellular Localizations

Cytoplasm. Nucleus. Secreted.

Diseases

Hypercalcemia
Malignant Neoplasms
Neoplasms
Humoral Hypercalcemia Of Malignancy (disorder)
Carcinoma
Neoplasm Metastasis
Malignant Paraganglionic Neoplasm
Malignant Squamous Cell Neoplasm
Bone Neoplasms
Metastatic Malignant Neoplasm To The Bone
Mammary Neoplasms
Malignant Neoplasm Of Breast

Lung Neoplasms
Paraneoplastic Syndromes
Adenocarcinoma
Malignant Neoplasm Of Lung
Leukemia
Osteosarcoma
Adult T-cell Lymphoma/leukemia

Interacting Proteins

PTH1R

Pathways

Secretion
Bone Resorption
Pathogenesis
Localization
Cell Growth
Cell Proliferation
Transport
Lactation
Excretion
Ossification
Chondrocyte Differentiation
Translation
Reverse Transcription

Bone Development
Cell Cycle
Bone Remodeling
Chondrocyte Proliferation
Protein Secretion
Angiogenesis
Endochondral Ossification

PTMs

Phosphorylation
Cleavage
Methylation
Glycosylation
Demethylation

Biotinylation
Iodination
Nitration
Farnesylation
Acetylation

Prenylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTHLH

References

PMID: 3616618 by Suva L.J., et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

PMID: 2829195 by Mangin M., et al. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.