Anti-PEAR1 Antibody

Product Name

Anti-PEAR1 Antibody

View all Pear1 Antibodies

SKU/Catalog Number

A09593

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-PEAR1 Antibody (Catalog # A09593). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

PEAR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-PEAR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09593)

Host

Rabbit

Contents

PEAR1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

PEAR1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PEAR1. The immunogen is located within the last 50 amino acids of PEAR1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.

Reactive Species

A09593 is reactive to PEAR1 in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

110666 MW

Background of Pear1

Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A09593 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

PEAR1 antibody can be used for detection of PEAR1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For PEAR1 (Source: Uniprot.org, NCBI)

Alternative Names

JEDI, MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, hPEAR1 Pear1|3110045G13Rik, Jedi-, Jedi-1, Megf12|platelet endothelial aggregation receptor 1|platelet endothelial aggregation receptor 1|Jedi|jagged and Delta protein|mPEAR1|multiple EGF-like domains protein 12|multiple epidermal growth factor-like domains protein 12|protein Jedi

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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