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Product Info Summary
| SKU: | A04903 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-PAK6 Antibody
SKU/Catalog Number
A04903
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PAK6 Antibody (Catalog # A04903). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
PAK6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PAK6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04903)
Host
Rabbit
Contents
PAK6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PAK6 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK6. The immunogen is located within amino acids 260 - 310 of PAK6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PAK6 antibody is predicted to not cross-react with other PAK family proteins.
Reactive Species
A04903 is reactive to PAK6 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
74869 MW
Background of PAK6
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04903 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PAK6 antibody can be used for the detection of PAK6 by Western blot at 1 - 4 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PAK6 in Raji lysate with PAK6 antibody at (A) 1
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Immunocytochemistry of PAK6 in Raji cells with PAK6 antibody at 10 μg/mL.
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Immunofluorescence of PAK6 in Raji cells with PAK6 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PAK6 (Source: Uniprot.org, NCBI)
Gene Name
PAK6
Full Name
Serine/threonine-protein kinase PAK 6
Weight
74869 MW
Superfamily
protein kinase superfamily
Alternative Names
PAK5, PAK5, PAK-5, PAK-6 PAK6 PAK5 p21 (RAC1) activated kinase 6 serine/threonine-protein kinase PAK 6|p21 protein (Cdc42/Rac)-activated kinase 6|p21(CDKN1A)-activated kinase 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PAK6, check out the PAK6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PAK6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PAK6 Antibody (A04903)
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