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PAK6 Antibodies
AND PAK6 ELISA kits, PAK6 Proteins
Many biological assays use antibodies to detect PAK6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK6 antibodies...
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PAK6 Overview
Facts about Serine/threonine-protein kinase PAK 6.
Serine/threonine-protein kinase PAK 6 (PAK6)
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors such as AR or MAP2K6/MAPKK6.
Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK6 |
| Uniprot: | Q9NQU5 |
| Entrez: | 56924 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK5EC 2.7.11.1; PAK6; PAK-6; serine/threonine-protein kinase PAK 6
Molecular Weight
Mass (kDA):
74.869 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q15.1 |
| Sequence: | 15; NC_000015.10 (40239063..40277487) |
Tissue Specificity
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
Subcellular Localizations
Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Malignant Neoplasm Of Breast
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Nervousness
- Learning Disorders
- Spinal Cord Injuries
- Malignant Tumor Of Colon
- Neoplasm Invasiveness
Interacting Proteins
- LRRK2
- RHOJ
Pathways
- Cell Motility
- Dna Methylation
- Methylation
- Cell Cycle
- Protein Phosphorylation
- Cell Proliferation
- Cell Division
- Cell Death
- Cell Migration
- Stem Cell Development
- Cell Development
- Regulation Of Cytoskeleton
- Dna Repair
PTMs
- Phosphorylation
- Methylation
Research Areas
- Breast Cancer
- Cancer
- DNA Repair
- GPCR
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK6
bosterbio.com/bosterbio-gene-info-cards/PAK6
References
PMID: 11278661 by Yang F., et al. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6.
PMID: 11773441 by Lee S.R., et al. AR and ER interaction with a p21-activated kinase (PAK6).