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Product Info Summary
| SKU: | A05512 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Nucleoporin GLE1 Gle1 Antibody
SKU/Catalog Number
A05512
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Nucleoporin GLE1 Gle1 Antibody (Catalog # A05512). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Gle1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Nucleoporin GLE1 Gle1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05512)
Host
Rabbit
Contents
Gle1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Gle1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human Gle1. The immunogen is located within amino acids 540 - 590 of Gle1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.
Reactive Species
A05512 is reactive to GLE1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
79836 MW
Background of GLE1
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05512 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Gle1 antibody can be used for detection of Gle1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Gle1 in mouse brain tissue lysate with Gle1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of Gle1 in mouse brain tissue with Gle1 antibody at 2.5 μg/mL.
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Immunofluorescence of gle1 in mouse brain tissue with gle1 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GLE1 (Source: Uniprot.org, NCBI)
Gene Name
GLE1
Full Name
Nucleoporin GLE1
Weight
79836 MW
Superfamily
GLE1 family
Alternative Names
LCCS, GLE1L, LCCS1, hGLE1, Nucleoporin GLE1, GLE1-like protein GLE1 CAAHC, CAAHDL, LCCS, LCCS1, hGLE1, GLE1 GLE1 RNA export mediator nucleoporin GLE1|GLE1 RNA export mediator homolog|GLE1-like protein|GLE1-like, RNA export mediator
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GLE1, check out the GLE1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GLE1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Nucleoporin GLE1 Gle1 Antibody (A05512)
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