Anti-Neuropilin-2 NRP2 Antibody Picoband®

Neuropilin-2 antibody

Boster Bio Anti-Neuropilin-2 NRP2 Antibody catalog # PA1771. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Info Summary

SKU: PA1771
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

Product Name

Anti-Neuropilin-2 NRP2 Antibody Picoband®

View all Neuropilin-2 Antibodies

SKU/Catalog Number

PA1771

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Neuropilin-2 NRP2 Antibody catalog # PA1771. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Neuropilin-2 NRP2 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1771)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human NRP2, identical to the related mouse sequence and different from the related rat sequence by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1771 is reactive to NRP2 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

105 kDa

Calculated molecular weight

104859 MW

Background of Neuropilin-2

NRP2 (Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped on 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in Npn2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1771 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Rat, Human, Mouse

Positive Control

WB: Rat Brain Tissue, Rat Testis Tissue

Validation Images & Assay Conditions

Gene/Protein Information For NRP2 (Source: Uniprot.org, NCBI)

Gene Name

NRP2

Full Name

Neuropilin-2

Weight

104859 MW

Superfamily

neuropilin family

Alternative Names

Neuropilin-2;Vascular endothelial cell growth factor 165 receptor 2;NRP2;VEGF165R2; NRP2 NP2, NPN2, PRO2714, VEGF165R2 neuropilin 2 neuropilin-2|neuropilin-2a(17)|neuropilin-2a(22)|neuropilin-2b(0)|receptor for VEGF165 and semaphorins class3|vascular endothelial cell growth factor 165 receptor 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on NRP2, check out the NRP2 Infographic

NRP2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for NRP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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4 Customer Q&As for Anti-Neuropilin-2 NRP2 Antibody Picoband®

Question

We are currently using anti-NRP2 antibody PA1771 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on monkey tissues as well?

Verified Customer

Verified customer

Asked: 2020-01-15

Answer

The anti-NRP2 antibody (PA1771) has not been tested for cross reactivity specifically with monkey tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in monkey you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2020-01-15

Question

I was wanting to use your anti-NRP2 antibody for WB for mouse brain on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for mouse brain identification?

Verified Customer

Verified customer

Asked: 2019-06-05

Answer

It shows on the product datasheet, PA1771 anti-NRP2 antibody has been validated for WB on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in mouse brain in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-06-05

Question

Would anti-NRP2 antibody PA1771 work on bovine WB with lower esophagus?

E. Johnson

Verified customer

Asked: 2016-05-26

Answer

Our lab technicians have not validated anti-NRP2 antibody PA1771 on bovine. You can run a BLAST between bovine and the immunogen sequence of anti-NRP2 antibody PA1771 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated bovine samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in bovine lower esophagus in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2016-05-26

Question

Is a blocking peptide available for product anti-NRP2 antibody (PA1771)?

M. Walker

Verified customer

Asked: 2013-07-16

Answer

We do provide the blocking peptide for product anti-NRP2 antibody (PA1771). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2013-07-16

Order DetailsPrice
PA1771

100μg

$370
PA1771-10ug

10μg sample (liquid)

$99
PA1771-Biotin

100 μg Biotin conjugated

$570
PA1771-Cy3

100 μg Cy3 conjugated

$570
PA1771-Dylight488

100 μg Dylight488 conjugated

$570
PA1771-Dylight550

100 μg Dylight550 conjugated

$570
PA1771-Dylight594

100 μg Dylight594 conjugated

$570
PA1771-FITC

100 μg FITC conjugated

$570
PA1771-HRP

100 μg HRP conjugated

$570
PA1771-APC

100 μg APC conjugated

$670
PA1771-PE

100 μg PE conjugated

$670
PA1771-iFluor647

100 μg iFluor647 conjugated

$670
PA1771-carrier-free

Carrier Free

$370

More conjugates/formats

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PA1771
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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