Product Info Summary
SKU: | PA1594 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®
View all Mineralocorticoid R/NR3C2 Antibodies
SKU/Catalog Number
PA1594
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody catalog # PA1594. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1594)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2, identical to the related mouse and rat sequences.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1594 is reactive to NR3C2 in Human, Mouse, Rat
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Observed Molecular Weight
84 kDa
Calculated molecular weight
107067 MW
Background of Mineralocorticoid R/NR3C2
NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
PA1594 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For NR3C2 (Source: Uniprot.org, NCBI)
Gene Name
NR3C2
Full Name
Mineralocorticoid receptor
Weight
107067 MW
Superfamily
nuclear hormone receptor family
Alternative Names
Mineralocorticoid receptor;MR;Nuclear receptor subfamily 3 group C member 2;NR3C2;MCR, MLR; NR3C2 MCR, MLR, MRVIT, NR3C2 nuclear receptor subfamily 3 group C member 2 mineralocorticoid receptor|aldosterone receptor|mineralocorticoid receptor 1|mineralocorticoid receptor 2|mineralocorticoid receptor delta|nuclear receptor subfamily 3, group C, member 2 variant 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NR3C2, check out the NR3C2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NR3C2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband® (PA1594)
Hello CJ!
PA1594 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells
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Customer Q&As
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1 Customer Q&As for Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®
Question
Is the anti-mineralocotroid receptor antibody (PA1594) better than the anti-NR3C2 antibody (PB9765) in detecting mineralocorticoid receptor (MR) in mouse liver and adipose tissue?
Verified Customer
Verified customer
Asked: 2019-08-12
Answer
PB9765 is better in detecting MR in mouse liver and adipose tissue.
Boster Scientific Support
Answered: 2019-08-12