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Key=sku, value=PA1594
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Key=created_at, value=2014-07-06 15:18:48
Key=updated_at, value=2024-10-19 05:02:55
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®
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Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=Mineralocorticoid Receptor/NR3C2 Antibody PA1594
Key=meta_description, value=Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody catalog # PA1594. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
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Key=url_key, value=anti-nr3c2-antibody-pa1594-boster
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Key=size, value=100 μg/vial
Key=protein_name, value=Mineralocorticoid receptor(MR)
Key=gene_full_name, value=Mineralocorticoid receptor
Key=uniprot_id, value=P08235
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Key=predicted_reactivity
Key=source_company, value=Boster PA1594
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=107067 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Atherosclerosis, Cardiovascular, Domain Families, Epigenetics and Nuclear Signaling, Hypertrophy, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription, Zinc Finger
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek1210-2-ELISA-human-sparc-picokine-elisa-kit.jpg
Key=rating_value, value=100
Key=review_count, value=12
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Key=cj_related_products, value=Bartter Disease:M10736^Pseudohypoaldosteronism:M05141|PA1939|A00747^Pseudohypoaldosteronism, Type 1:A01413-1|M01413
Key=description, value=Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody catalog # PA1594. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody catalog # PA1594. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-Mineralocorticoid Receptor/NR3C2 Antibody
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Key=background, value=NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Key=gene_name, value=NR3C2
Key=synonyms, value=Mineralocorticoid receptor;MR;Nuclear receptor subfamily 3 group C member 2;NR3C2;MCR, MLR;
Key=application_details, value=Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Key=subcellular_localization, value= Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Key=sequence_similarities, value=Belongs to the nuclear hormone receptor family. NR3 subfamily.
Key=tissue_specificity, value= Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. .
Key=protein_function, value= Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. .
Key=application_notes, value=Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 11412|sc 11412 X|sc 53000|sc 6860|sc 6860 X|sc 6861|sc 6861 X|sc 71554
Key=immunogen, value=A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2, identical to the related mouse and rat sequences.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
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