NR3C2 Antibodies

AND NR3C2 ELISA kits, NR3C2 Proteins

Many biological assays use antibodies to detect NR3C2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR3C2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR3C2 antibodies...

We validate the specificity of these antibodies to NR3C2 by testing them on tissues known to express NR3C2 positively and negatively. Browse below to find the NR3C2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NR3C2 Infographic by Boster Bio

All NR3C2 Products

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Specificity

Applications

Price

Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®

1 Citations 6 Q&As

Human, Mouse, Rat

IF, ICC, WB

$370
Cat # PB9765
100 μg/vial

Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®

1 Citations

Human, Mouse, Rat

$370
Cat # PA1594
100 μg/vial

NR3C2 Overview

Facts about Mineralocorticoid receptor.

NR3C2 3D structure. Source: alphafold

Mineralocorticoid receptor (NR3C2)

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes.

The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. .

Gene Information

Human
Gene Name:	NR3C2
Uniprot:	P08235
Entrez:	4306

Family

Belongs to:

nuclear hormone receptor family

Alternative Names

FLJ41052; MGC133092; Mineralocorticoid R; mineralocorticoid receptor 1; mineralocorticoid receptor delta; MineralocorticoidR; MLR; MLRmineralocorticoid receptor; MRMCRaldosterone receptor; NR3C2; NR3C2VIT; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2

Molecular Weight

Mass (kDA):
107.082 kDA

Genomic Context


Human

Location:	4q31.23
Sequence:	4; NC_000004.12 (148078764..148444698, complement)

Tissue Specificity

Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.

Subcellular Localizations

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.

Diseases

Pseudohypoaldosteronism
Hypertensive Disease
Pseudohypoaldosteronism, Type 1
Failure To Thrive
Depressive Disorder
Essential Hypertension
Dehydration
Malnutrition
Malignant Tumor Of Cervix
Carcinoma
Bartter Disease
Neoplasms

Mammary Neoplasms
Stress, Psychological
Heart Failure
Physiological Stress
Major Depressive Disorder
Mood Disorders
Infarction

Pathways

Pathogenesis
Transport
Vasodilation
Lactation
Habituation
Immune Response
Proteolysis
Energy Homeostasis
Localization
Glomerular Filtration

Response To Risperidone
Vasoconstriction
Excretion
Oncogenesis
Secretion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR3C2

References

PMID: 3037703 by Arriza J.L., et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.

PMID: 11518808 by Zennaro M.-C., et al. A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.

1 Publications of Boster NR3C2 Antibodies & ELISA Kits

PubMed ID: 26646587, GPER is involved in the stimulatory effects of aldosterone in breast cancer cell...

*More publications can be found for each product on its corresponding product page