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Product Info Summary
| SKU: | A07838 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NALP7 NLRP7 Antibody
SKU/Catalog Number
A07838
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NALP7 NLRP7 Antibody (Catalog # A07838). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
NALP7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NALP7 NLRP7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07838)
Host
Rabbit
Contents
NALP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of OTUD4 are known to exist. OTUD4 antibody is predicted to not cross-react with other members of the OTUD family.
Reactive Species
A07838 is reactive to NLRP7 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
111807 MW
Background of NLRP7
NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07838 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NALP7 antibody can be used for detection of NALP7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NALP7 in K562 cell lysate with NALP7 antibody at 2 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 μg/mL.
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Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NLRP7 (Source: Uniprot.org, NCBI)
Gene Name
NLRP7
Full Name
NACHT, LRR and PYD domains-containing protein 7
Weight
111807 MW
Superfamily
NLRP family
Alternative Names
HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4, NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12 NLRP7 CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3 NLR family pyrin domain containing 7 NACHT, LRR and PYD domains-containing protein 7|NACHT, LRR and PYD containing protein 7|NACHT, leucine rich repeat and PYD containing 7|PYRIN-containing Apaf1-like protein 3|nucleotide-binding oligomerization domain protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NLRP7, check out the NLRP7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NLRP7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NALP7 NLRP7 Antibody (A07838)
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