Anti-MMP-11 Antibody

Product Name

Anti-MMP-11 Antibody

View all MMP-11 Antibodies

SKU/Catalog Number

A04490

Size

100ul

Form

Liquid

Description

Boster Bio Anti-MMP-11 Antibody catalog # A04490. Tested in WB,ICC/IF,IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MMP-11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04490)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human SRp55

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04490 is reactive to MMP11 in Human, Mouse, Rat

Applications

A04490 is guaranteed for IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

54590 MW

Background of MMP-11

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Yeh E.T.H., Gene 248:1-14(2000).
Choi S.J., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Wiemann S., Genome Res. 11:422-435(2001).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1,000
ICC: 1:500-1:1,000
IHC: 1:100-1:500

Validation Images & Assay Conditions

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Figure 2. Immunocytochemistry staining of MMP11 using Anti-MMP-11 Antibody (A04490).

ICC staining MMP11 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde

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Figure 1. Western blotting validation for Anti-MMP-11 Antibody A04490

Western blot analysis of MMP11 on mouse spleen lysates using anti-MMP11 antibody at 1/1

Gene/Protein Information For MMP11 (Source: Uniprot.org, NCBI)

Alternative Names

EC 3.4.24; EC 3.4.24.-; EC 3.4.24.24; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP11; MMP-11; SL-3; ST3; STMY3stromelysin 3; stromelysin III; stromelysin-3 MMP11 SL-3, ST3, STMY3 matrix metallopeptidase 11 stromelysin-3|matrix metallopeptidase 11 (stromelysin 3)|stromelysin III

For more info on MMP11, check out the MMP11 Infographic

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In this infographic, you will see the following information for MMP11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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