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Product Info Summary
| SKU: | A02699 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-NAIP Antibody
SKU/Catalog Number
A02699
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NAIP Antibody (Catalog # A02699). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
NAIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NAIP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02699)
Host
Rabbit
Contents
NAIP Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP. The immunogen is located within amino acids 1200 - 1250 of NAIP.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Minor, lower molecular weight bands may represent alternately spliced forms.
Reactive Species
A02699 is reactive to NAIP in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
159582 MW
Background of NAIP
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02699 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NAIP antibody can be used for the detection of NAIP by Western blot at 0.5 to 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NAIP in human tonsil tissue lysate with NAIP antibody at 1 μg/mL.
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Immunocytochemistry of NAIP in A549 cells with NAIP antibody at 10 μg/mL.
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Immunofluorescence of NAIP in A549 cells with NAIP antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NAIP (Source: Uniprot.org, NCBI)
Gene Name
NAIP
Full Name
Baculoviral IAP repeat-containing protein 1
Weight
159582 MW
Alternative Names
BIRC1, NLRB1, psiNAIP, BIRC1, Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein NAIP BIRC1, NLRB1, psiNAIP NLR family apoptosis inhibitory protein baculoviral IAP repeat-containing protein 1|neuronal apoptosis inhibitory protein|nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1|psi neuronal apoptosis inhibitory protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NAIP, check out the NAIP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NAIP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NAIP Antibody (A02699)
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