NAIP Antibodies

AND NAIP ELISA kits, NAIP Proteins

Many biological assays use antibodies to detect NAIP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAIP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAIP antibodies...

We validate the specificity of these antibodies to NAIP by testing them on tissues known to express NAIP positively and negatively. Browse below to find the NAIP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NAIP Infographic by Boster Bio

All NAIP Products

Product

Figures

Specificity

Applications

Price

Anti-NAIP Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A02699
0.1 mg

Anti-NAIP Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02699-1
100ul

Anti-NAIP Rabbit Monoclonal Antibody

Human

$370
Cat # M02699
100 μl/vial

NAIP Overview

Facts about Baculoviral IAP repeat-containing protein 1.

NAIP 3D structure. Source: alphafold

Baculoviral IAP repeat-containing protein 1 (NAIP)

Anti-apoptotic protein that acts by inhibiting the actions of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9.

Capable of inhibiting CASP9 autoproteolysis in'Asp-315' and decreasing the rate of automobile proteolysis in'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions.

Gene Information

Human
Gene Name:	NAIP
Uniprot:	Q13075
Entrez:	4671

Family

Belongs to:

No superfamily

Alternative Names

baculoviral IAP repeat-containing 1; BIRC1; BIRC1baculoviral IAP repeat-containing protein 1; FLJ18088; FLJ42520; FLJ58811; NAIP; Neuronal apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein; NLR family, BIR domain containing 1; NLRB1; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1; psi neuronal apoptosis inhibitory protein; psiNAIP

Molecular Weight

Mass (kDA):
159.582 kDA

Genomic Context


Human

Location:	5q13.2
Sequence:	5; NC_000005.10 (70968166..71025339, complement)

Tissue Specificity

Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.

Diseases

Spinal Muscular Atrophy
Atrophy
Muscular Atrophy
Spinal Muscular Atrophies Of Childhood
Malignant Neoplasms
Neoplasms
Weakness
Nerve Degeneration
Neuromuscular Diseases
Inflammation
Hmn (hereditary Motor Neuropathy) Proximal Type I
Neurodegenerative Disorders
Muscle Weakness

Legionnaires' Disease
Motor Neuron Disease
Nervousness
Leukemia
Sclerosis
Amyotrophic Lateral Sclerosis
Primary Lateral Sclerosis

Pathways

Cell Death
Pathogenesis
Programmed Cell Death
Gene Conversion
Secretion
Cell Proliferation
Muscle Atrophy
Immune Response
Cytokine Production
Cell Differentiation
Cell Cycle
Induction Of Apoptosis
Localization

Methylation
Cell Growth
Cell Division
Oncogenesis
Dna Methylation
Dna Repair
Disease Resistance

PTMs

Cleavage
Ubiquitination

Phosphorylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NAIP

References

PMID: 7813013 by Roy N., et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy.

PMID: 9503025 by Chen Q., et al. Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.