Anti-Musk Antibody

MUSK antibody

Boster Bio Anti-Musk Antibody (Catalog # M00815). Tested in IHC-P, WB application(s). This antibody reacts with Mouse, Rat.

Product Info Summary

SKU: M00815
Size: 80 µl
Reactive Species: Mouse, Rat
Host: Mouse
Application: IHC-P, WB

Product Name

Anti-Musk Antibody

View all MUSK Antibodies

SKU/Catalog Number

M00815

Size

80 µl

Description

Boster Bio Anti-Musk Antibody (Catalog # M00815). Tested in IHC-P, WB application(s). This antibody reacts with Mouse, Rat.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-Musk Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00815)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Monoclonal

Clone Number

1429CT456.173.44

Isotype

IgG1,k

Immunogen

This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00815 is reactive to Musk in Mouse, Rat

Reconstitution

Calculated molecular weight

96693 Da

Background of MUSK

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M00815 is guaranteed for IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:2000
IHC-P: 1:25

Validation Images & Assay Conditions

Gene/Protein Information For Musk (Source: Uniprot.org, NCBI)

Gene Name

Musk

Full Name

Muscle, skeletal receptor tyrosine-protein kinase

Weight

96693 Da

Superfamily

protein kinase superfamily

Alternative Names

Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor, Musk, Nsk2 MUSK CMS9, FADS, FADS1 muscle associated receptor tyrosine kinase muscle, skeletal receptor tyrosine-protein kinase|muscle, skeletal, receptor tyrosine kinase|muscle-specific kinase receptor|muscle-specific tyrosine-protein kinase receptor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on Musk, check out the Musk Infographic

Musk infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for Musk: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M00815-80ul

80 μl

$299
M00815-400ul

400 μl

$347

Free Secondary Antibody

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M00815
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$299.00

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