Anti-MTCO1/MT-CO1 Antibody Picoband®

MT-CO1 antibody

Boster Bio Anti-MTCO1/MT-CO1 Antibody catalog # PA1317-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Info Summary

SKU: PA1317-1
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IHC, ICC, WB

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Product Name

Anti-MTCO1/MT-CO1 Antibody Picoband®

View all MT-CO1 Antibodies

SKU/Catalog Number

PA1317-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-MTCO1/MT-CO1 Antibody catalog # PA1317-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MTCO1/MT-CO1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1317-1)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MTCO1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1317-1 is reactive to MT-CO1 in Human

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

37 kDa

Calculated molecular weight

57041 MW

Background of MT-CO1

Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. It is composed of 13 polypeptides. Subunits I, II, and III (MTCO1, MTCO2, MTCO3) are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, and VIII are nuclear encoded. The cytochrome c oxidase family of enzymes have 4 redox centers, 2 hemes and 2 copper centers. In mitochondrial Complex IV, the 2 hemes are a and a3 and the 2 coppers are CuA and CuB. The 2 hemes and CuB are bound to subunit I. Acin-Perez et al. (2003) identified a cell line containing single and double missense mutations in the cytochrome c oxidase (COX) subunit I gene of mouse mitochondrial DNA. And they hypothesized that deleterious mutations can arise and become predominant; cultured cells can maintain several mtDNA haplotypes at stable frequencies; the respiratory chain has little spare COX capacity; and that the size of a cavity in the vicinity of val421 in MTCO1I of animal COX may affect the function of the enzyme.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1317-1 is guaranteed for IHC, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunocytochemistry , 0.5-1μg/ml, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: human HeLa mitochondria at 20ug, human HeLa whole cell at 20ug, human Caco-2 whole cell, rat heart tissuemouse heart tissue
IHC: human mammary cancer tissue
ICC: C6 Cell

Validation Images & Assay Conditions

Gene/Protein Information For MT-CO1 (Source: Uniprot.org, NCBI)

Gene Name

MT-CO1

Full Name

Cytochrome c oxidase subunit 1

Weight

57041 MW

Superfamily

heme-copper respiratory oxidase family

Alternative Names

Cytochrome c oxidase subunit 1;1.9.3.1;Cytochrome c oxidase polypeptide I;MT-CO1;COI, COXI, MTCO1;

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on MT-CO1, check out the MT-CO1 Infographic

MT-CO1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for MT-CO1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
PA1317-1

100μg

$370
PA1317-1-10ug

10μg sample (liquid)

$99
PA1317-1-Biotin

100 μg Biotin conjugated

$570
PA1317-1-Cy3

100 μg Cy3 conjugated

$570
PA1317-1-Dylight488

100 μg Dylight488 conjugated

$570
PA1317-1-Dylight550

100 μg Dylight550 conjugated

$570
PA1317-1-Dylight594

100 μg Dylight594 conjugated

$570
PA1317-1-FITC

100 μg FITC conjugated

$570
PA1317-1-HRP

100 μg HRP conjugated

$570
PA1317-1-APC

100 μg APC conjugated

$670
PA1317-1-PE

100 μg PE conjugated

$670
PA1317-1-iFluor647

100 μg iFluor647 conjugated

$670
PA1317-1-carrier-free

Carrier Free

$370

More conjugates/formats

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PA1317-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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