MT-CO1 Antibodies

Cytochrome c oxidase subunit 1 (MT-CO1)

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex.

CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Gene Information

Human
Gene Name:	MT-CO1
Uniprot:	P00395
Entrez:

Family

Belongs to:
heme-copper respiratory oxidase family

Alternative Names

Cytochrome c oxidase subunit 1

Molecular Weight

Mass (kDA):
57.041 kDA

Genomic Context

Human
Location:
Sequence:	;

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein.

Diseases

• Leber hereditary optic neuropathy (LHON)

Interacting Proteins

• COA3
• COX4I1
• TIMM21

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MT-CO1

Best Uses Of The MT-CO1 Marker

There are numerous biological assays which utilize the MTCO1 Marker to detect a variety of different molecules. Boster Bio has created monoclonal and polyclonal antibodies designed to recognize MT-CO1. MT-CO1 is an enzyme compound with three subunits. Each has a distinct purpose in cell cycle and proliferation.

MT-CO1 Marker

The risk of developing heart disease has been linked to the MTCO1 marker, which is present in monocytes. The marker has not yet been established to be causally linked to disease, however it is a promising new method for risk stratification and monitoring of patients. It is possible to discern the MTCOI-specific traces in plasma monocytes, which could allow for further research into its predictive capacity.

The MT-CO1 gene is a human ortholog of the cytochrome C oxidase. The protein is a component of the electron transport chain pathway and interacts with substances including (S)-nicotine, 17alpha-ethynylestradiol, and 17beta-estradiol. It was first isolated from a bacterial colony, and then sequenced.

MT-CO1 Marker for cell proliferation

In this study, we utilized the MT-CO1 marker to analyze the quality of the methylation of prostate cancer cells. To treat PC3 cells as well as the cancer cell line of 22Rv1 we administered one dose of ddC. After treatment the cells were taken and split into two parts. In the second section we ran qPCR with the MT-CO1 mtDNA locus normalized to the C2 gene , or the nuclear DNA gene.

This gene can also be used as a biomarker to detect CVD. It is well-known for its ability to predict CVD risk. It is also used to determine the methylation of the platelet in the bloodstream, which is another CVD biomarker. We can calculate the area under the receiver operating characteristic (ROC) curve for the MTCO1 gene and other genes . We then contrast the results with the results obtained from the two samples.

Mm-mt-Co1 is a key protein in cell growth. The isthmus of the rat is higher levels of mtDNA than the more affluent glands. The signal strength of mtDNA is different in different tissues, depending on whether the cell is stem cells, a proliferative cell , or an endothelial tissue. In these studies, mtDNA signals were visualized through hybridization using a mouse Mm-mt-Co1 sense probe and was developed by DAB chromogen.

The MTCO1 gene is a component of the mitochondrial respiratory chain IV. It is orthologous with the human MTCO1 gene. Human mtDNA is homologous MT-CO1.

Marker MT-CO1 to regulate cell cycle

The MTCO1 gene, a member of the mitochondria, plays a crucial role in the cell cycle. It also regulates the cellular response insulin. Numerous studies have demonstrated that human cells express this gene in different ways. Cluster 12 showed a dramatic increase in genes involved with the development of oligodendrocytes, neutrophil chemotaxis and development. Other studies have revealed that cluster 9 cells also express genes that are related to hyperoxia and aerobic respiration. Cluster 12 cells also showed an increase in synaptic-related genes and cellular response insulin.