Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody

Product Name

Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody

View all Integrin beta 2/CD18 Antibodies

SKU/Catalog Number

M00458-3

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody (Catalog# M00458-3). Tested in Flow Cytometry, IP, WB, IHC-P, IHC-F application(s). This antibody reacts with Mouse.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00458-3)

Host

Rat

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

M18/2

Isotype

Rat IgG2a

Immunogen

Murine cytotoxic T cell glycoproteins. The rat monoclonal antibody M18/2 recognizes an extracellular epitope of CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00458-3 is reactive to Itgb2 in Mouse

Reconstitution

Observed Molecular Weight

19 kDa

Calculated molecular weight

85026 MW

Background of Integrin beta 2/CD18

CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M00458-3 is guaranteed for Flow Cytometry, IP, IHC-P, IHC-F, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1 μg/ml.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For Itgb2 (Source: Uniprot.org, NCBI)

Alternative Names

Integrin beta2, Complement receptor C3 subunit beta, ITGB2 ITGB2 CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin subunit beta 2 integrin beta-2|cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement component 3 receptor 3 and 4 subunit|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)|leukocyte cell adhesion molecule CD18|leukocyte-associated s CD18/11A, CD18/11B, CD18/11C|truncated integrin beta-2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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