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Product Info Summary
| SKU: | M04466-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Mouse |
| Host: | Rat |
| Application: | Flow Cytometry, IP, IHC-F |
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Product info
Product Name
Anti-Ms CD11a Purified Itgal Monoclonal Antibody
SKU/Catalog Number
M04466-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Ms CD11a Purified Itgal Monoclonal Antibody (Catalog# M04466-2). Tested in Flow Cytometry, IP, IHC-F application(s). This antibody reacts with Mouse.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Ms CD11a Purified Itgal Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04466-2)
Host
Rat
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
M17/4
Isotype
Rat IgG2a
Immunogen
C57BL/6 mouse splenic secondary cytotoxic T lymphocytes. The rat monoclonal antibody M17/4 reacts with an extracellular epitope of CD11a (alpha-subunit of murine LFA-1), a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M04466-2 is reactive to ITGAL in Mouse
Reconstitution
Observed Molecular Weight
19 kDa
Calculated molecular weight
60149 MW
Background of ITGAL
CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M04466-2 is guaranteed for Flow Cytometry, IP, IHC-F Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1 μg/ml.
Immunohistochemistry (frozen sections): Positive tissue: murine spleen or thymus, acetone fixation.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For ITGAL (Source: Uniprot.org, NCBI)
Gene Name
ITGAL
Full Name
Integrin alpha-L
Weight
60149 MW
Superfamily
integrin alpha chain family
Alternative Names
LFA-1, LFA1A, ITGAL ITGAL CD11A, LFA-1, LFA1A integrin subunit alpha L integrin alpha-L|CD11 -like family member A|LFA-1 alpha|LFA-1A| CD11A (p180), lymphocyte function-associated 1, alpha polypeptide|integrin gene promoter|integrin, alpha L ( CD11A (p180), lymphocyte function-associated 1; alpha polypeptide)|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte function-associated 1, alpha polypeptide
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ITGAL, check out the ITGAL Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ITGAL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Ms CD11a Purified Itgal Monoclonal Antibody (M04466-2)
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