Anti-MAP4K6 MINK1 Antibody

Product Name

Anti-MAP4K6 MINK1 Antibody

View all MAP4K6 Antibodies

SKU/Catalog Number

A06134

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-MAP4K6 MINK1 Antibody (Catalog # A06134). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MAP4K6 MINK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06134)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human MAP4K6.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A06134 is reactive to MINK1 in Human, Mouse

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Calculated molecular weight

149822 MW

Background of MAP4K6

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Dan I., FEBS Lett. 469:19-23(2000).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Olsen J.V., Cell 127:635-648(2006).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A06134 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For MINK1 (Source: Uniprot.org, NCBI)

Alternative Names

Misshapen-like kinase 1;2.7.11.1;GCK family kinase MiNK;MAPK/ERK kinase kinase kinase 6;MEK kinase kinase 6;MEKKK 6;Misshapen/NIK-related kinase;Mitogen-activated protein kinase kinase kinase kinase 6;MINK1 ;B55, MAP4K6 , MINK , YSK2, ZC3; MINK1 B55, MAP4K6, MINK, YSK2, ZC3 misshapen like kinase 1 misshapen-like kinase 1|GCK family kinase MINK|MAPK/ERK kinase kinase kinase 6|MEK kinase kinase 6|MEKKK 6|misshapen/NIK-related kinase|mitogen-activated protein kinase kinase kinase kinase 6

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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