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Misshapen-like kinase 1 Antibodies
AND MINK1 ELISA kits, Misshapen-like kinase 1 Proteins
Many biological assays use antibodies to detect Misshapen-like kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Misshapen-like kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Misshapen-like kinase 1 antibodies...
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MINK1 Infographic by Boster Bio
All MINK1 Products
Product
Figures
Specificity
Applications
Price
Anti-MAP4K6 MINK1 Antibody
5 Q&As
Human, Mouse
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # A30524
100ul
Cat # A30524
100ul
MINK1 Overview
Facts about Misshapen-like kinase 1.
Misshapen-like kinase 1 (MINK1)
Serine/threonine kinase which functions as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons.
Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of this stress-activated protein kinase MAPK14/p38 MAPK downstream of this Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1.
Gene Information
| Human | |
|---|---|
| Gene Name: | MINK1 |
| Uniprot: | Q8N4C8 |
| Entrez: | 50488 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
B55; EC 2.7.11; GCK family kinase MiNK; hMINK; hMINKbeta; MAP4K6EC 2.7.11.1; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MGC21111; MINKMEKKK 6; Misshapen/NIK-related kinase; misshapen-like kinase 1 (zebrafish); misshapen-like kinase 1; Mitogen-activated protein kinase kinase kinase kinase 6; serine/threonine protein kinase; YSK2; ZC3
Molecular Weight
Mass (kDA):
149.822 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.2 |
| Sequence: | 17; NC_000017.11 (4833340..4898061) |
Tissue Specificity
Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
Subcellular Localizations
Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, dendrite.; [Isoform 4]: Golgi apparatus.
Diseases
- Cell Invasion
- Cell Transformation, Neoplastic
- Syncope
- Stenosis
- Cardiac Arrhythmia
- Long Qt Syndrome
- Malignant Neoplasm Of Breast
- Tissue Adhesions
- Carcinoma
- Fibrosarcoma
- Sudden Death
Interacting Proteins
- HSF1
- IER5
Pathways
- Cell Cycle
- Cell Adhesion
- Transport
- Convergent Extension
- Protein Transport
- Abscission
- Localization
- Cell Cycle Arrest
- Cytokinesis
- Senescence
PTMs
Research Areas
- GPCR
- MAP Kinase Signaling
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MINK1
bosterbio.com/bosterbio-gene-info-cards/MINK1
References
PMID: 10708748 by Dan I., et al. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development.
PMID: 15469942 by Hu Y., et al. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.