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Product Info Summary
| SKU: | A07806-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LZTS2 Antibody
SKU/Catalog Number
A07806-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LZTS2 Antibody (Catalog # A07806-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LZTS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07806-1)
Host
Rabbit
Contents
LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LZTS2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human LZTS2. The immunogen is located within amino acids 80 - 130 of LZTS2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LZTS2 antibody is predicted to not cross-react with other LZTS family members
Reactive Species
A07806-1 is reactive to LZTS2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
72759 MW
Background of LZTS2
The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07806-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LZTS2 antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LZTS2 in human kidney tissue lysate with LZTS2 antibody at 1 μg/mL.
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Immunohistochemistry of LZTS2 in human kidney tissue with LZTS2 antibody at 2.5 μg/mL.
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Immunofluorescence of LZTS2 in human kidney tissue with LZTS2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LZTS2 (Source: Uniprot.org, NCBI)
Gene Name
LZTS2
Full Name
Leucine zipper putative tumor suppressor 2
Weight
72759 MW
Superfamily
LZTS2 family
Alternative Names
LAPSER1, KIAA1813, LAPSER1, Leucine zipper putative tumor suppressor 2, Protein LAPSER1, hLZTS2 LZTS2 LAPSER1 leucine zipper tumor suppressor 2 leucine zipper putative tumor suppressor 2|leucine zipper, putative tumor suppressor 2|protein LAPSER1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LZTS2, check out the LZTS2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LZTS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LZTS2 Antibody (A07806-1)
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