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Product Info Summary
| SKU: | A00688-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | Flow Cytometry, IF, IHC-P, WB |
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Product info
Product Name
Anti-TP73 Antibody (Center)
SKU/Catalog Number
A00688-1
Size
80 µl
Form
Liquid
Description
Boster Bio Anti-TP73 Antibody (Center) (Catalog # A00688-1). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human, Mouse.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-TP73 Antibody (Center) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00688-1)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This TP73 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the Central region of human TP73.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00688-1 is reactive to TP73 in Human, Mouse
Reconstitution
Calculated molecular weight
69623 Da
Background of p73
TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00688-1 is guaranteed for Flow Cytometry, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IF: 1:10-1:50
WB: 1:1000
IHC-P: 1:50-1:100
FC: 1:10-1:50
Validation Images & Assay Conditions
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Confocal immunofluorescent analysis of TP73 Antibody (Center) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
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TP73 Antibody (Center) western blot analysis in K562 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the TP73 antibody detected the TP73 protein (arrow).
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TP73 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TP73 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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TP73 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Protein Target Info & Infographic
Gene/Protein Information For TP73 (Source: Uniprot.org, NCBI)
Gene Name
TP73
Full Name
Tumor protein p73
Weight
69623 Da
Superfamily
p53 family
Alternative Names
Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73 TP73 P73 tumor protein p73 tumor protein p73|p53-like transcription factor|p53-related protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TP73, check out the TP73 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TP73: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TP73 Antibody (Center) (A00688-1)
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