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- Table of Contents
Facts about Leucine zipper putative tumor suppressor 2.
May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are essential for transportation within the elongating axon. Negative regulator of the Wnt signaling pathway.
Human | |
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Gene Name: | LZTS2 |
Uniprot: | Q9BRK4 |
Entrez: | 84445 |
Belongs to: |
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LZTS2 family |
hLZTS2; KIAA1813leucine zipper putative tumor suppressor 2; LAPSER1Protein LAPSER1; leucine zipper, putative tumor suppressor 2
Mass (kDA):
72.759 kDA
Human | |
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Location: | 10q24.31 |
Sequence: | 10; NC_000010.11 (100997065..101007836) |
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
PMID: 11709705 by Cabeza-Arvelaiz Y., et al. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.
PMID: 17000760 by Thyssen G., et al. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.