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Product Info Summary
| SKU: | A04523 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-LXR-B NR1H2 Antibody
View all LXR beta/NR1H2 Antibodies
SKU/Catalog Number
A04523
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LXR-B NR1H2 Antibody (Catalog # A04523). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LXR-B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LXR-B NR1H2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04523)
Host
Rabbit
Contents
LXR-B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LXR-B antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B. The immunogen is located within the first 50 amino acids of LXR-B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of PIBF1 exists as a result of alternative splicing event.
Reactive Species
A04523 is reactive to NR1H2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
50974 MW
Background of LXR beta/NR1H2
LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04523 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LXR-B antibody can be used for detection of LXR-B by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LXR-B in human lung tissue lysate with LXR-B antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NR1H2 (Source: Uniprot.org, NCBI)
Gene Name
NR1H2
Full Name
Oxysterols receptor LXR-beta
Weight
50974 MW
Superfamily
nuclear hormone receptor family
Alternative Names
NER, UNR, LXRB, LXR-b, NER-I, RIP15, NER, Oxysterols receptor LXR-beta, Liver X receptor beta NR1H2 LXR-b, LXRB, NER, NER-I, RIP15, UNR nuclear receptor subfamily 1 group H member 2 oxysterols receptor LXR-beta|LX receptor beta|liver X nuclear receptor beta|nuclear orphan receptor LXR-beta|nuclear receptor NER|steroid hormone-nuclear receptor NER|ubiquitously-expressed nuclear receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NR1H2, check out the NR1H2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NR1H2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LXR-B NR1H2 Antibody (A04523)
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