NR1H2 Antibodies

AND NR1H2 ELISA kits, NR1H2 Proteins

Many biological assays use antibodies to detect NR1H2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR1H2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR1H2 antibodies...

We validate the specificity of these antibodies to NR1H2 by testing them on tissues known to express NR1H2 positively and negatively. Browse below to find the NR1H2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NR1H2 Infographic by Boster Bio

All NR1H2 Products

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Product

Figures

Specificity

Applications

Price

Anti-LXR-B NR1H2 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A04523
0.1 mg

Anti-LXR beta/NER/NR1H2 Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04523-2
100 μg/vial

LXR beta (NR1H2) (NM_007121) Human Over-expression Lysate

Human

$628
Cat # LS007376
100 µg

NR1H2 Overview

Facts about Oxysterols receptor LXR-beta.

NR1H2 3D structure. Source: alphafold

Oxysterols receptor LXR-beta (NR1H2)

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats with the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).

Regulates cholesterol uptake through MYLIP- dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).

Gene Information

Human
Gene Name:	NR1H2
Uniprot:	P55055
Entrez:	7376

Family

Belongs to:

nuclear hormone receptor family

Alternative Names

Liver X receptor beta; LXR beta; LXR-b; NER-I; NERliver X receptor-beta; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptorLXRB; UNR; UNRLX receptor beta

Molecular Weight

Mass (kDA):
50.974 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (50376457..50383388)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus.

Diseases

Diabetes Mellitus
Cardiovascular Diseases
Hypercholesterolemia
Alzheimer's Disease
Malignant Neoplasms
Atherosclerosis
Neurodegenerative Disorders
Pre-eclampsia
Cell Invasion
Steatosis
Diabetes Mellitus, Non-insulin-dependent
Inflammation
Niemann-pick Diseases

Prediabetes Syndrome
Dyslipidemias
Pregnancy Complications
Inflammatory Bowel Diseases
Persistant Generalized Lymphadenopathy
Malignant Neoplasm Of Urinary Bladder
Intestinal Diseases

Interacting Proteins

ABCA1
CORO2A
MDFI
NCOR1
PPARD

PPARG
RXRA

Pathways

Cholesterol Homeostasis
Transport
Cholesterol Efflux
Cholesterol Transport
Reverse Cholesterol Transport
Lipid Homeostasis
Secretion
Luteolysis
Cell Proliferation
Regulation Of Cholesterol Homeostasis
Response To Lipid
Insulin Secretion
G1 Phase

Keratinocyte Differentiation
Cell Cycle Arrest
Fatty Acid Homeostasis
Cell Cycle
Response To Cholesterol
Pathogenesis
Rna Interference

PTMs

Phosphorylation

Hydroxylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1H2

References

PMID: 7926814 by Shinar D.M., et al. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.

PMID: 20159957 by Venteclef N., et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.