Anti-LKB1/STK11 Antibody Picoband®

Product Name

Anti-LKB1/STK11 Antibody Picoband®

View all LKB1/STK11 Antibodies

SKU/Catalog Number

PB9270

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-LKB1/STK11 Antibody Picoband® catalog # PB9270. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-LKB1/STK11 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9270)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human LKB1 recombinant protein (Position: K62-C430). Human LKB1 shares 89% amino acid (aa) sequence identity with both mouse and rat LKB1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9270 is reactive to STK11 in Human

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

60 kDa

Calculated molecular weight

48636 MW

Background of LKB1/STK11

Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PB9270 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: 293T Whole Cell, HT1080 Whole Cell, SHG Whole Cell, JURKAT Whole Cell, Human Placenta Tissue

Validation Images & Assay Conditions

Gene/Protein Information For STK11 (Source: Uniprot.org, NCBI)

Alternative Names

Serine/threonine-protein kinase STK11;2.7.11.1;Liver kinase B1;LKB1;hLKB1;Renal carcinoma antigen NY-REN-19;STK11;LKB1, PJS; STK11 LKB1, PJS, hLKB1 serine/threonine kinase 11 serine/threonine-protein kinase STK11|liver kinase B1|polarization-related protein LKB1|renal carcinoma NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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