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Product Info Summary
| SKU: | A13256-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LGI2 Antibody
SKU/Catalog Number
A13256-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LGI2 Antibody (Catalog # A13256-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
LGI2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LGI2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13256-1)
Host
Rabbit
Contents
LGI2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LGI2 antibody was raised against a 10 amino acid synthetic peptide from near the center of human LGI2. The immunogen is located within amino acids 290 - 340 of LGI2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.
Reactive Species
A13256-1 is reactive to LGI2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
63006 MW
Background of LGI2
The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A13256-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LGI2 antibody can be used for the detection of LGI2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LGI2 in mouse liver tissue lysate with LGI2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemical staining of human brain tissue using LGI2 antibody at 2.5 μg/mL.
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Immunofluorescence of LGI2 in Human Brain cells with LGI2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LGI2 (Source: Uniprot.org, NCBI)
Gene Name
LGI2
Full Name
Leucine-rich repeat LGI family member 2
Weight
63006 MW
Alternative Names
mKIAA1916, Kiaa1916, Leucine-rich repeat LGI family member 2, Leucine-rich glioma-inactivated protein 2 LGI2 LGIL2 leucine rich repeat LGI family member 2 leucine-rich repeat LGI family member 2|LGI1-like protein 2|leucine-rich glioma-inactivated protein 2|leucine-rich, glioma inactivated 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LGI2, check out the LGI2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LGI2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LGI2 Antibody (A13256-1)
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