Anti-Membrin Gosr2 Antibody

Product Name

Anti-Membrin Gosr2 Antibody

View all Membrin Antibodies

SKU/Catalog Number

A08717

Size

25μg/vial

Form

Liquid

Description

Boster Bio Anti-Membrin Gosr2 Antibody catalog # A08717. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store vial at -20°C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing. Expiration date is three (3) months from date of opening.

Cite This Product

Anti-Membrin Gosr2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08717)

Host

Rabbit

Contents

Each vial contains 25mM sodium borate, 100mM boric acid, 75mM sodium chloride, 5mM EDTA (disodium salt).

Clonality

Polyclonal

Isotype

IgG2b kappa

Immunogen

Synthetic peptide corresponding to a portion of rat membrin.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A08717 is reactive to GOSR2 in Human, Mouse, Rat

Applications

A08717 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

24607 MW

Background of Membrin

Epithelial splicing regulatory protein 1 (Esrp-1) and Esrp-2 are mRNA splicing factors that regulate the formation of epithelial cell-specific isoforms. They specifically regulate the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 and -2 act by directly binding specific sequences in mRNAs. They bind the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 2.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

User needs to optimize the dilution ratio for this antibody.

Validation Images & Assay Conditions

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Membrin was detected in paraffin-embedded sections of human liver tissues using rabbit anti-Membrin Antigen Affinity purified polyclonal antibody (Catalog # A08717) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).

Gene/Protein Information For GOSR2 (Source: Uniprot.org, NCBI)

Alternative Names

golgi SNAP receptor complex member 2; GS27Bos1,27 kDa Golgi SNARE protein; membrin GOSR2 Bos1, EPM6, GS27 golgi SNAP receptor complex member 2 Golgi SNAP receptor complex member 2|27 kDa Golgi SNARE protein|membrin

For more info on GOSR2, check out the GOSR2 Infographic

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In this infographic, you will see the following information for GOSR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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