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Product Info Summary
| SKU: | A01573 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, ICC, WB |
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Product info
Product Name
Anti-LAMP-2 Antibody
View all LAMP-2/CD107b Antibodies
SKU/Catalog Number
A01573
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LAMP-2 Antibody (Catalog # A01573). Tested in ELISA, WB, ICC, IHC-P applications. This antibody reacts with Human, Mouse.
Storage & Handling
LAMP-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LAMP-2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01573)
Host
Rabbit
Contents
LAMP-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LAMP-2. The immunogen is located within the last 50 amino acids of LAMP-2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LAMP-2 antibody cross reacts with LAMP2B and LAMP2C, but not LAMP2A.
Reactive Species
A01573 is reactive to LAMP2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
45681 MW
Background of LAMP-2/CD107b
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01573 is guaranteed for ELISA, IHC-P, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LAMP-2 antibody can be used for the detection of LAMP-2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LAMP-2 in HepG2 cell lysate with LAMP-2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of LAMP-2 in HepG2 cells with LAMP-2 antibody at 10 μg/mL.
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Immunohistochemistry of LAMP-2 in mouse liver tissue with LAMP-2 Antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LAMP2 (Source: Uniprot.org, NCBI)
Gene Name
LAMP2
Full Name
Lysosome-associated membrane glycoprotein 2
Weight
45681 MW
Superfamily
LAMP family
Alternative Names
Mac3, LGP-B, CD107b, Lamp-2, Lamp II, Lamp-2a, Lamp-2b, Lamp-2c, Lysosome-associated membrane glycoprotein 2, CD107 antigen-like family member B, LAMP-2 LAMP2 CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110 lysosomal associated membrane protein 2 lysosome-associated membrane glycoprotein 2|CD107 -like family member B
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LAMP2, check out the LAMP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LAMP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LAMP-2 Antibody (A01573)
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