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LAMP2 Antibodies
AND LAMP2 ELISA kits, LAMP2 Proteins
Many biological assays use antibodies to detect LAMP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LAMP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LAMP2 antibodies...
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LAMP2 Infographic by Boster Bio
All LAMP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01573
100 μl
Cat # M01573
100 μl
LAMP2 Overview
Facts about Lysosome-associated membrane glycoprotein 2.
Lysosome-associated membrane glycoprotein 2 (LAMP2)
Plays an essential part in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for its fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to collect STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032).
Gene Information
| Human | |
|---|---|
| Gene Name: | LAMP2 |
| Uniprot: | P13473 |
| Entrez: | 3920 |
Family
| Belongs to: |
|---|
| LAMP family |
Alternative Names
CD107 antigen-like family member B; CD107b antigen; CD107b; LAMP2; LAMP-2; LAMPB; LGP110; LGP-96; Lysosomal Associated Membrane Protein 2 ; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2
Molecular Weight
Mass (kDA):
44.961 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq24 |
| Sequence: | X; NC_000023.11 (120426148..120469349, complement) |
Tissue Specificity
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Diseases
- Danon Disease
- Cardiomyopathies
- Hypertrophy
- Myopathy
- Hypertrophic Cardiomyopathy
- Left Ventricular Hypertrophy
- Autophagic Vacuolar Myopathy
- Storage Disease
- Weakness
- Cardiomyopathy, Dilated
- Heart Failure
- Glycogen Storage Disease Type Ii
Pathways
- Autophagy
- Localization
- Pathogenesis
- Cell Death
- Transport
- Secretion
- Endocytosis
- Macroautophagy
- Rna Interference
- Secretory Pathway
- Glycosylation
- Aging
- Proteolysis
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Ubiquitination
Research Areas
- Cellular Markers
- Chaperone-Mediated Autophagy (CMA)
- Cognition and Behavior
- Growth and Development
- Immunology
- Innate Immunity
- Lipid and Metabolism
- Lysosome Markers
- Mast Cell Markers
- Membrane Trafficking and Chaperones
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LAMP2
bosterbio.com/bosterbio-gene-info-cards/LAMP2
References
PMID: 3198605 by Fukuda M., et al. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h- lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.
PMID: 8517882 by Sawada R., et al. The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.
1 Publications of Boster LAMP2 Antibodies & ELISA Kits
- PubMed ID: 30531012, Structural and functional damage to the hippocampal neurovascular unit in diabet...
*More publications can be found for each product on its corresponding product page