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Product Info Summary
| SKU: | A07812 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Kin of IRRE-like protein 2 KIRREL2 Antibody
View all Kirrel2/NEPH3 Antibodies
SKU/Catalog Number
A07812
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Kin of IRRE-like protein 2 KIRREL2 Antibody (Catalog # A07812). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
KIRREL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Kin of IRRE-like protein 2 KIRREL2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07812)
Host
Rabbit
Contents
KIRREL2 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
KIRREL2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KIRREL2. The immunogen is located within amino acids 550 - 600 of KIRREL2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.
Reactive Species
A07812 is reactive to KIRREL2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
75092 MW
Background of Kirrel2/NEPH3
KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07812 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of KIRREL2 in 293 cell lysate with KIRREL2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 μg/ml.
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Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For KIRREL2 (Source: Uniprot.org, NCBI)
Gene Name
KIRREL2
Full Name
Kin of IRRE-like protein 2
Weight
75092 MW
Superfamily
immunoglobulin superfamily
Alternative Names
Kin of irregular chiasm-like protein 2, Kin of IRRE-like protein 2, NEPH3, Nephrin-like protein 3, NLG1, FILTRIN KIRREL2 FILTRIN, NEPH3, NLG1 kirre like nephrin family adhesion molecule 2 kin of IRRE-like protein 2|kin of IRRE like 2|kin of irregular chiasm-like protein 2|nephrin-like gene 1|nephrin-like protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KIRREL2, check out the KIRREL2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KIRREL2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Kin of IRRE-like protein 2 KIRREL2 Antibody (A07812)
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