Anti-KCTD11 Antibody (N-Term)

Product Name

Anti-KCTD11 Antibody (N-Term)

View all KCTD11 Antibodies

SKU/Catalog Number

M10796

Size

50 µl

Description

Boster Bio Anti-KCTD11 Antibody (N-Term) (Catalog # M10796). Tested in WB, IHC-P application(s). This antibody reacts with Human, Mouse.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-KCTD11 Antibody (N-Term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M10796)

Host

Rabbit

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M10796 is reactive to KCTD11 in Human, Mouse

Applications

M10796 is guaranteed for IHC-P, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

25887 Da

Background of KCTD11

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000-1:2000
IHC-P: 1:25

Validation Images & Assay Conditions

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All lanes : Anti-KCTD11 Antibody (N-Term) at 1:1000-1:2000 dilution
Lane 1: human brain lysate
Lane 2: human cerebellum lysate
Lane 3: mouse cerebellum lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),

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AP21901a staining KCTD11 in human kidney tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen

Gene/Protein Information For KCTD11 (Source: Uniprot.org, NCBI)

Alternative Names

BTB/POZ domain-containing protein KCTD11; C17orf36; chromosome 17 open reading frame 36; MGC129844; potassium channel tetramerisation domain containing 11; REn; REN/KCTD11; RENpotassium channel tetramerization domain containing 11; retinoic acid, EGF, NGF induced gene protein; retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domaincontaining 11 KCTD11 C17orf36, KCASH1, REN, REN/KCTD11 potassium channel tetramerization domain containing 11 BTB/POZ domain-containing protein KCTD11|RING-type E3 ubiquitin transferase subunit KCTD11|potassium channel tetramerization domain-containing protein 11|retinoic acid, EGF, NGF induced gene protein

For more info on KCTD11, check out the KCTD11 Infographic

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In this infographic, you will see the following information for KCTD11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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