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Key=entity_id, value=2525
Key=attribute_set_id, value=4
Key=type_id, value=simple
Key=sku, value=PB9178
Key=has_options, value=0
Key=required_options, value=0
Key=created_at, value=2014-12-03 21:43:24
Key=updated_at, value=2024-09-26 00:46:11
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-KAT3B/p300/EP300 Antibody Picoband®
Key=cj_search_index
Key=publication_count, value=0
Key=qty_in_warehouses
Key=is_recurring, value=No
Key=visibility, value=Catalog, Search
Key=tax_class_id, value=Taxable Goods
Key=featured, value=No
Key=featured_image, value=Yes
Key=fb_product, value=
Key=custom_product_page, value=No
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Key=template, value=antibodies
Key=host, value=Rabbit
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Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1329
Key=yoast_content_score, value=30
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=KAT3B/p300/EP300 Antibody
Key=meta_description, value=Boster Bio Anti-KAT3B/p300/EP300 Antibody Picoband® catalog # PB9178. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
Key=image, value=/antibody/pb9178-1-WB-anti-kat3b-p300-picoband-antibody.jpg
Key=small_image, value=/antibody/pb9178-1-WB-anti-kat3b-p300-picoband-antibody.jpg
Key=thumbnail, value=/antibody/pb9178-1-WB-anti-kat3b-p300-picoband-antibody.jpg
Key=url_key, value=anti-kat3b-p300-picoband-trade-antibody-pb9178-boster
Key=url_path, value=anti-kat3b-p300-picoband-trade-antibody-pb9178-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Figure 1. Western blot analysis of KAT3B/p300 using anti-KAT3B/p300 antibody (PB9178).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours.
lane 1: recombinant human kat3b/p300 protein
Key=small_image_label, value=Figure 1. Western blot analysis of KAT3B/p300 using anti-KAT3B/p300 antibody (PB9178).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours.
lane 1: recombinant human kat3b/p300 protein
Key=thumbnail_label, value=Figure 1. Western blot analysis of KAT3B/p300 using anti-KAT3B/p300 antibody (PB9178).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours.
lane 1: recombinant human kat3b/p300 protein
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=protein_name, value=Histone acetyltransferase p300
Key=gene_full_name, value=Histone acetyltransferase p300
Key=uniprot_id, value=Q09472
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=IHC, WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Key=predicted_reactivity
Key=source_company, value=Boster PB9178
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=264161 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Chromatin Binding Proteins, DNA/RNA, DNA/RNA Binding, Epigenetics and Nuclear Signaling, RNA Processing, Splicing, Transcription
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek0750-2-ELISA-mouse-decorin-picokine-elisa-kit.jpg
Key=rating_value, value=97.7
Key=review_count, value=7
Key=phospho_site
Key=mp_exclude_sitemap, value=No
Key=yoast_focus_keyword, value=CD68 antibody
Key=yoast_facebook_image, value=no_selection
Key=yoast_twitter_image, value=no_selection
Key=cj_related_products, value=HIF Target Genes:EKC2316|M00368^Rubinstein-taybi Syndrome:A00205-1|EKC1924^Transcription Factors and Regulators:RP1072
Key=description, value=Boster Bio Anti-KAT3B/p300/EP300 Antibody Picoband® catalog # PB9178. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-KAT3B/p300/EP300 Antibody Picoband® catalog # PB9178. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-KAT3B/p300/EP300 Antibody Picoband®
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Key=background, value=E1A binding protein p300 also known as EP300 or p300 is a protein that in humans is encoded by the EP300 gene. The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This protein regulates the activity of many genes in tissues throughout the body. It plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The EP300 protein appears to be critical for normal development before and after birth. It carries out its function by activating transcription. In addition, the protein functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and differentiation. EP300 also mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
Key=gene_name, value=EP300
Key=synonyms, value=Histone acetyltransferase p300;p300 HAT;2.3.1.48 ;E1A-associated protein p300;EP300;P300;
Key=application_details, value=Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human

Key=subcellular_localization, value= Cytoplasm. Nucleus. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Key=sequence_similarities, value=Contains 1 bromo domain.
Key=tissue_specificity, value= Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. .
Key=application_notes, value=WB: The detection limit for KAT3B is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 130210|sc 161548|sc 161549|sc 161550|sc 161551|sc 161553|sc 167734|sc 167737|sc 32244|sc 32244 X|sc 48343|sc 48343 X|sc 49002|sc 49002 X|sc 49003|sc 49003 X|sc 514902|sc 56455|sc 584|sc 584 X|sc 585|sc 585 X|sc 8981|sc 8981 X|sc 98922|sc 98922 X|sc 98923|sc 98923 X
Key=immunogen, value=E.coli-derived human KAT3B recombinant protein (Position: L2065-H2414). Human KAT3B shares 94% amino acid (aa) sequence identity with mouse KAT3B.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=300 kDa
Key=custom_attribute_2, value=WB: human COLO-320 whole cell, rat PC-12 whole cell, mouse NIH3T3 whole cell
IHC: mouse intestine tissue, rat intestine tissue, human oesophagus squama cancer tissue
Key=protein_function, value= Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D. .
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