Anti-Interferon regulatory factor 8 IRF8 Antibody Picoband®

Product Name

Anti-Interferon regulatory factor 8 IRF8 Antibody Picoband®

View all IRF8 Antibodies

SKU/Catalog Number

PA2209

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Interferon regulatory factor 8 IRF8 Antibody catalog # PA2209. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Interferon regulatory factor 8 IRF8 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2209)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human IRF8, different from the related mouse and rat sequences by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2209 is reactive to IRF8 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

47 kDa

Calculated molecular weight

48356 MW

Background of IRF8

Interferon regulatory factor 8 (IRF8) also known as Interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. By genomic sequence analysis, the IRF8 gene is mapped to chromosome 16q24.1. Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA2209 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: RAJI Cell, Rat Liver Tissue, Rat Kidney Tissue,

Validation Images & Assay Conditions

Gene/Protein Information For IRF8 (Source: Uniprot.org, NCBI)

Alternative Names

Interferon regulatory factor 8;IRF-8;Interferon consensus sequence-binding protein;H-ICSBP;ICSBP;IRF8;ICSBP1; IRF8 H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8 interferon regulatory factor 8 interferon regulatory factor 8|interferon consensus sequence binding protein 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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